Flow Chemistry India 2017: Conference Summary

J Michael Koehler, HOD, Technische Universitat IImenau, Germany

Flow Chemistry India 2017: Conference Summary

Author: Aditya Chachad, Correspondent, Sci Journo 

 

 

Day 1 of Conference

SELECTBIO’s 5th International Conference on  Flow Chemistry was held at Ramada Powai Hotel & Convention Centre, Mumbai. Conference was conducted on two days 18th  and 19th January 2017. Proceedings were started by welcome address delivered by Sanjay Bajaj MD, SELECTBIO. Dr Richard Jones Secretary, SFS, Flow Chemistry Society gave a short introduction regarding Flow Chemistry. Advancement of Flow Chemistry in India was  enumerated by Dr Vijay Kirpalani, President, Flow Chemistry Society- India Chapter.

Day One comprised of three sessions with each session chaired by renowned individuals from the industry. Each session covered different topics from Flow Chemistry. Session 1 topic:  Transforming industrial chemistry through flow. First speech was delivered by Dr Ian Baxendale, Professor Department of Chemistry, Durham University, UK. His topic ‘Small molecules and flow chemistry’ in which topics like Scaling up building blocks- separation, evapouration of the reaction, Synthesis of fragrance components, Scale out synthesis in flow, Hydrazine formulation in flow, Heterogeneous flow mixtures, Polar bear flow synthesis. Second speech was of  Dr Anil Kumar Professor, Department of Chemistry, IIT Bombay on topic ‘ Continuous flow process: A new paradigm in polymers and material synthesis’, his speech comprised of Reasons of conducting flow fast reactions, Rapid construction of chemical libraries, On demand rapid synthesis, Challenges in nanoelectronics- efficiency, lifespan, cost, reliability etc, Continuous flow synthesis- stoichiometric conditions, Insolubility of catalyst, very fast reaction, Kumada coupling, Nanoparticles via flow process. Third speech was delivered by Dr Charlotte Wiles, CEO, Chemtrix BV, Netherlands on the topic of ‘Applications of process intensification  tools to fine chemical and pharmaceuticals production’. Her speech was relatively focused on Fundamentals of flow chemistry, Opportunities for greater process control, Process intensification, Online monitoring FTIR, SIC corrosion resistant reactor. Session one commences which was headed by Kuber Jagdale, Head-API Manufacturing, Cipla.

 

Attendees at Flow Chemistry India 2017

 

Successful implementation of continuous flow manufacturing which was chaired by Vilas H Dahanukar, chief scientist, Process R&D, Dr Reddy’s laboratories. First speech was delivered  by Paul Watts, Professor & Research chair in microfluidic bio/chemical processing , NMMU, South Africa his topics were highy based on Flow chemistry original expectations: use for high value manufacture, pharmaceuticals, high value fine chemicals, Challenges in South Africa: availability of chemicals, imports to be done from Europe, China, India etc. New technologies which are implemented like Falling film reactor, packed bed reactor, silane synthesis, pyridine synthesis. Availability of AIDS drugs in South Africa, necessity of international collaboration with countries which developing tremendously in Pharmaceuticals and the need to train high quality scientist and leaders. Second speech in that session was of Sandeep Jain Sun Pharmaceuticals Industries, on the topic ‘Benfits and barriers to implementation of continuous manufacturing. His speech comprised of Increase Lab development, enabling manufacture efficiency, technical and business challenges. Vijay Kirplani delivered the third speech on ‘Techno-commercial road map to develop a business case for continuous flow manufacturing on Main drivers for process development, cost reduction options, manufacturing opportunities, technical opportunities of CFM, technical advantages of CFM, process challenges, API intermediates, aromatic nitration Andrea Adamo, CEO of Zaiput Flow technologies, USA explained topics on Intergrated liquid liduid separator like Zaiput flow technology, multiple extraction and counter current extraction.

Third session’s topics was solely based on ‘Processs engineering for continuous flow manufacturing, chaired by D P Kudav of University of Mumbai. Dr Amol Kulkarni, Scientist National Chemical Laboratory delivered the session’s first speech on Chemical Engineer’s view on Multistep flow synthesis on terms like Application at lab scale, bioactive molecules, process of using commercially available starting material, setup requirements, engineer in flow synthesis, synthesis of phenyl hydrazine. Dr Robert Ashe MD AM Technolgy UK delivered speech on ‘ Flow chemistry- The process defines the rules’ on the areas of Scale up and scale down -2 aspects of process development, controlling temperature in scale up, zero order reaction and nth order reaction , solid handling. Last speech of the day was delivered by Dr Duncan Browne a lecturer in organic chemistry of Cardiff University UK on the topic ‘Application of Diazonium salts in multistep continuous flow process’ on topics solely based on Organic chemistry like Proposed mechanism of ascorbic acid mediated reduction of diazonium salts, synthesis of pyrazole iridium complexes, synthesis of Indoles, triazines. Day one of the conference concludes.

Day 2 of Conference

19th January comprised of 3 sessions along with Flash presentations at the end of the day. Session 4 commences on the topic ‘Diversity of Flow chemistry applications’ chaired by MMV Ramana , Professor and HOD of Chemistry, Unversity of Mumbai. First speech of J Michael Koelher of Technische Universitat llmenau, Germany on ‘Micro flow synthesis of metals and composite particles for catalytic and sensor applications’ on Micro reaction technology, gold nanocubes, gold polymer, silver nanotriangles, combinatorial segment flow experiments. Second speech of the  day was again delivered by again by Charlotte Wiles due as Dr Daniel Mink was unavailable. His topic was ‘impact of additive manufacturing on micro reactor technology main topics of the speech were Impact of fluid velocity, manufacturing of industrial flow reactor and development of  micro flow reactor. Ajay K Singh of CSIR IICT Hyderabad delivered a speech on Micro total process system for API Synthesis on notable mentions like micro tale envelope systems, generation-seperation reactions and interfacial catalytic gas-liquid micro total process synthesis. Last speech of the session was delivered by Dr Wouter Stam MD Flowid products, Netherlands which was a company presentation on Spinning desk reactor, chimex and spinpro reactor.

Dr Prathama Mainkar, Sr Scientist CSIR-IICT, Hyderabad chaired the 5th session on Strategies from R&D to Market. Manjinder Singh, unit head R&D Cipla delivered a speech on Strategies to accelerated the R&D by research intensification on the topics Tradtional approach in R&D, research and process intensification, significance of flow chemistry in R&D. Sandeep Kattamuri COO Glochem Industries delivered the speech on Regulatory pathway on continuous manufacturing and US-FDA guidance. Notable mentions in his presentations were New drug manufacturing applications, change in managements of existing DMFs, consideration for controlled strategy for continuous marketing. Before lunch an interactive session was conducted among the speakers and delegates.

Continuous bio processing and automation in flow chaired by P Shrihari, principal scientist CSIR-IICT Hyderabad consisted of last two speaker of which Lazlo Poppe, Professor, Department for Organic Chemistry, Budhapest University, Hungary on Immobilized enzymes in novel continuous- flow reactor systems and Richard Jones, CCO, Thales Nano Inc, Hungary on Envisioning the future of chemical synthesis on earth and among the stars. Final session of the conference was of Flash presentations on DoE in Flow chemistry, Automation and Digitalization: enabling compliant CFM, Selection guide for flow reactors, pumps, distillations, crystallization, filitartion and drying, continuous cost effective  chromatographic  purification.

Conclusion

SELECTBIO’s 5th International Conference on Flow Chemistry was a successful conference with over 18 speakers from USA, Europe, India and South Africa. Interaction between the delegates and speakers was influential and speakers ensured that Flow chemistry is an arising field with better job prospective  and there is a  need to include its topics in academics as the current scenario states students hardly about flow chemistry in their graduation as well as post gradutation. Sci Journo feels proud to be media partner for such knowledgeable events that provide way by which scientific excellence is achieved and we are the part of that progress.

 

 

 

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